TB-500

Overview

What it is, in plain language

TB-500 is a synthetic peptide based on the active region of Thymosin Beta-4, a naturally occurring protein involved in actin regulation and cellular migration. Where BPC-157 acts as a localised signal, TB-500 works systemically — mobilising cells to where they're needed and supporting tissue repair across longer distances and broader systems.

Its long systemic half-life distinguishes it from peptides requiring daily administration. Weekly dosing maintains effect, which is why TB-500 sits at the centre of any protocol where the repair load is broad rather than localised.

TB-500 mobilises the cells that BPC-157 signals — the two operate on complementary timescales and stack cleanly within the same window.

Mechanism

How it works

Research describes TB-500's central activity as actin sequestration and release, which governs cell migration. It is investigated for roles in angiogenesis, anti-fibrotic action, and the recruitment of stem and progenitor cells to repair sites.

Research findings

What the literature shows

Animal studies indicate accelerated healing of dermal wounds, muscle injuries, and cardiac tissue. Anti-fibrotic effects have been observed.

The long systemic activity of TB-500 distinguishes it from peptides requiring daily administration — weekly dosing maintains effect through the circulating half-life.

Cycle & Handling

Protocol reference

Common research-grade reference figures. Not medical advice — every protocol must be reviewed against the latest published literature and your study design.

Cycle guidance

Run full loading-plus-maintenance up to twice yearly. Total annual exposure ~16–24 weeks. Do not stack back-to-back loading phases — the long systemic half-life means circulating peptide remains weeks after the final dose. Pairs naturally with BPC-157 (classic recovery stack) and with GHK-Cu for aesthetic crossover.

Reconstitution

2 mL BAC → 5 mg/mL. Draw 0.4 mL = 2 mg; 0.5 mL = 2.5 mg.

Storage

Lyophilised vial: room temperature short-term, refrigerator long-term. Reconstituted: refrigerate; use within 28 days when reconstituted with bacteriostatic water.

FAQ