Research Notes

CJC-1295 with DAC

Sustained GH signal.

Lyophilised powder
Format
2.5–5 weeks
Vial coverage
2 mL BAC water
Reconstitution

Overview

What it is, in plain language

CJC-1295 with DAC is a long-acting GHRH (growth-hormone releasing hormone) analogue. The "DAC" (Drug Affinity Complex) is a small bonding group that allows the peptide to attach to circulating albumin, extending its half-life from minutes to approximately one week.

This shifts dosing from daily injections to once-weekly administration, and shifts the physiological effect from short pulses to a sustained "GH bleed" — a continuous low-level elevation of growth hormone and IGF-1.

The DAC modification turns CJC-1295 from a pulsatile compound into a sustained-elevation one — a different protocol, not a longer version of the same protocol.

Mechanism

How it works

Binds the GHRH receptor in the pituitary, stimulating growth-hormone release. The DAC modification extends serum half-life to ~7 days by anchoring the molecule to albumin, producing sustained receptor engagement rather than pulsatile activation.

Research findings

What the literature shows

Animal and limited human studies report sustained elevation of GH and IGF-1 with weekly dosing. Effects on lean mass, recovery, and skin/connective tissue have been observed.

The sustained-elevation pattern is distinguishable from the pulsatile pattern produced by CJC-1295 without DAC and is best regarded as a different protocol entirely, not simply a longer-acting variant.

Cycle & Handling

Protocol reference

Common research-grade reference figures. Not medical advice — every protocol must be reviewed against the latest published literature and your study design.

Cycle guidance

Standard 8–12 weeks on, 4 weeks off. Annual ceiling: 2–3 cycles. Typically run solo rather than stacked with the CJC-NoDAC + Ipamorelin combination — the sustained DAC elevation undermines the pulsatility that makes the NoDAC stack work. Some protocols pair the DAC with low-dose Ipamorelin for added GH amplitude.

Reconstitution

2 mL BAC → 2.5 mg/mL. Draw 0.4 mL = 1 mg; 0.8 mL = 2 mg.

Storage

Lyophilised vial: room temperature short-term, refrigerator long-term. Reconstituted: refrigerate; use within 28 days when reconstituted with bacteriostatic water.

FAQ