MOTS-c

Overview

What it is, in plain language

MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA. Unlike most peptides, it originates from the mitochondria themselves, acting as a metabolic regulator that communicates with the rest of the cell.

Research has positioned MOTS-c as a key signal in exercise, metabolic flexibility, and the aging process. It is consistently described in the literature as a "training-paired" compound — the effects are amplified when administration overlaps with a structured training block.

MOTS-c is encoded inside the mitochondrion itself — a metabolic signal sent from the energy organelle out to the rest of the cell.

Mechanism

How it works

MOTS-c is reported to activate the AMPK pathway, a central regulator of cellular energy. Research findings include enhanced glucose uptake, improved insulin sensitivity, and increased fat utilisation in animal models.

Research findings

What the literature shows

Animal studies have reported sustained improvements in glucose homeostasis and exercise capacity.

Effects appear to be amplified by training during the dosing window — MOTS-c is consistently described as a "training-paired" compound in the literature, and the on-phase is usually scheduled to overlap with a structured training block.

Cycle & Handling

Protocol reference

Common research-grade reference figures. Not medical advice — every protocol must be reviewed against the latest published literature and your study design.

Cycle guidance

Standard 4–8 weeks on, 2–4 weeks off. Extended 12-week protocols seen in dedicated metabolic research. Annual ceiling: 2–3 cycles. Best paired with a structured training block during the on-phase. After 8+ weeks, washout helps re-assess whether benefits persist or require re-dosing.

Reconstitution

2 mL BAC → 10 mg/mL. Draw 0.5 mL = 5 mg; 1.0 mL = 10 mg.

Storage

Lyophilised vial: room temperature short-term, refrigerator long-term. Reconstituted: refrigerate; use within 28 days when reconstituted with bacteriostatic water.

FAQ